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Dynamics of Fibronectin Type III Domains


Carr, P.A., Erickson, H.P., & Palmer, A.G. (1997) Backbone dynamics of homologous fibronectin type III domains from fibronectin and tenascin. Structure 5, 949-959.

Akke, M., Liu, J., Cavanagh, J., Erickson, H.P., & Palmer, A.G. (1998) Pervasive conformational fluctuations on microsecond time scales in a fibronectin type III domain. Nat. Struct. Biol. 5, 55-59.


Dynamics of the tenth type III domain of human fibronectin as represented on a backbone chain trace of the crystal structure 1fna. The 15N order parameters are coded as the width of the backbone worm (increased radii indicate lower order parameters and greater degree of conformational flexibility), and the color coding indicates the presence (yellow) or absence (red) of conformational exchange. The RGD motif, important for interactions with integrins, is colored blue for emphasis.

Dynamics of the third type III domain of human tenascin-C as represented on a backbone chain trace of the crystal structure 1ten, solved by Leahy and coworkers in the Hendrickson lab here at Columbia University. The 15N order parameters are coded as the width of the backbone worm (increased radii indicate lower order parameters and greater degree of conformational flexibility), and the color coding indicates the presence (yellow) or absence (red) of conformational exchange. The RGD motif, important for interactions with integrins, is colored blue for emphasis.

Microsecond conformational exchange dynamics of the third type III domain of human tenascin-C as represented on a ba ckbone chain trace of the crystal structure 1ten, solved by Leahy and coworkers in the Hendrickson lab here at Columbia University. The values of the exchange time are color-coded onto the chain trace from blue (30 microseconds) to cyan (120 microseconds). Exchange times greater than 120 microseconds are represented by yellow. The amplitude factors are represented by the width of the backbone worm ranging from 0.9 to 3.4 ppm (assuming equal populations of exchanging sites).


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Last modified 7/25/02 Kemal Eren. Send comments to agp6@columbia.edu